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HāF Equipment Acquires Semi-Bulk Systems, Expanding Ingredient Handling Capabilities

HāF Equipment Acquires Semi-Bulk Systems, Expanding Ingredient Handling Capabilities…Read More

Pneumatic Blending – Back to the Basics

Pneumatic Blending

by: Jared Beaupre

Companies struggle with keeping their material handling equipment clean. especially the inside of the equipment.  For example, have you ever tried to clean an industrial-sized mixer, like a ribbon blender? With most industrial equipment, like mechanical mixers, it can be labor-intensive, and dangerous, to ensure the unit is effectively cleaned and that the backsides of all the mixing paddles are clean. The tiny crevices in the design are out of sight but not out of mind. But, what if we told you that you could blend your dry powders without a mechanical-oriented mixer? Imagine a blender that is just as clean and simple as an empty hopper and cone! At HaF Equipment, we have the solution: Pneumatic Blenders!

Using simple compressed air, a pneumatic blender pulses a bubble of air into the centerline of the cone. That air pushes a column of the dry material upward, like taking a core sample or cross-section of the stratified material. As the column of material moves upward, the air expands and accelerates to throw that material into the headspace of the hopper. It is this motion that creates the mixing action.

The motion of the material also creates an aeration effect that creates a fluidized state for the material. When in a fluidized state, the material is free-flowing. So, as that column of material lifts, the remaining material around the side walls freely flows down and replaces the material blown upward. The mixing of powders happens quickly, with no mechanical friction.

When Pneumatic Blending is Best

Pneumatic blending isn’t for all applications, however. It is best when an extremely quick and accurate blend is needed. Since the blending action isn’t a “folding over” or “mass cutting,” the blend is extremely homogenous in a very short period. Rather than a blend measured in tens of minutes, most pneumatic blends can be accomplished in less than a minute. All of this is, however, dependent on the material blended. Material that is easily fluidizable, such as flour, glass bubbles, or powders for ceramics, work extremely well. Materials that are large particles, such as stones or nuts, are not good candidates since the air tends to flow through the material, not allowing the column of material to lift.

Comparing Blender Types

  • RIBBON blender.

    A Ribbon Blender typically has a U-shaped horizontal trough and then a custom fabricated ribbon agitator that spins to mix powders. The pros to the ribbon blender are that it operates at a cost-effective price point and offers high capacity.  Pneumatic blending can also work with large tonnages.  Unfortunately, the ribbon blender does not fill all the way and is often left with dead space (unused space). Another downfall to the ribbon blender is that it can be dusty, especially around the mechanical seals.  Pneumatic blending is sealed tight and is a simple hopper in concept.  The ribbon blender also tends to have a larger footprint and can sometimes damage the product in production.  Pneumatic blending is essentially a simple hopper and cone with air pistons in the cone.  The pneumatic blender is gentle in regard to damaging product.  It uses compressed air, not stainless-steel agitators.

  • PADDLE blender. A mixing paddle blender uses a custom fabricated paddle, typically mounted on a shaft, which can be inserted on the shaft end into the end of a motor drive assembly.  The paddle blender offers large capacity, with reduced RPM. On the flip side, the paddle blender is not proven to be efficient, and the gearbox located on the top of the vessel can be a hindrance. 

  • TUMBLER or V blender.

    V blenders are rotary mixers, also called tumble blenders. Just like how it sounds, the shape of the machine is a “V”.  The V is formed by welding together two cylinders.  The whole unit rotates allowing the powders to mix.  This is called diffusive (or dispersion) mixing. In diffusive mixing, the particles of solids move randomly, typically rolling down when their container is rotated. The motion is driven by gravity and falling particles.  There is no mechanical agitator or ribbon.

    There are no agitators inside the V blender, all the movement of the powder comes from gravity and the rotation of the shell. Since there is no agitator, it will perform “ok” with free-flowing solids, but it is less effective with cohesive powders. 

    The benefit of the V blender is that is has smooth internal surfaces that results in a more sanitary design.  But this is the same with pneumatic blending where the inside of the vessel is sanitary smooth.

    You get the clean vessel with the pneumatic blender as needed in pharmaceuticals, and the pneumatic blender is ultra-sanitary. The tumble blender tends to be more expensive, offers low capacity, and does an “ok” job with mixing.

Pneumatic Blender

Pneumatic Blender Flexibility – Powders & Liquids

The applications and variations of the Pneumatic Blender are vast and can be used for varying applications depending on the industry. Coatings or flavor additions are a great way to use pneumatic blending with liquids.  Pneumatic blenders can also be used for fluidizing silos and aid in silo discharge of ingredient powders.

When the pneumatic blender is put at the bottom of a dense phase conveyor vessel, it can receive the powders in, blend, and dense phase convey the powders long distances.  This is extremely helpful when you want to blend powders in a powder dedicated room, and then send the blended batch of powders to a production line elsewhere in the manufacturing facility.  This set up is very flexible.

Lastly, this system can utilize inert gas to blend combustible powders.

Pneumatic Blender - HaF Equipment

Summary:
HaF Equipment is here to assist you with which application would benefit from pneumatic blending; and seeing is believing. So, contact a HaF account manager today to see what options we can provide to test the blender. We can do this in our facility with your material, or directly at your facility to give real-time results with as many in-plant conditions as possible. At HaF, we are Ready to Connect!

CONTACT US today to discuss your pneumatic blending equipment needs. 

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About HaF Equipment

HaF is a Minnesota-based company with employees spread out across the USA and capabilities world-wide. We’re ready to support your manufacturing industry needs no matter where you live or what type of industry – we’ve got our finger on the pulse Ready to Connect. 

For more information about how we can help you meet your goals, don’t hesitate to call us at (651) 653-5098, or complete the Contact Form on our website.

Segregation Challenges in Pharmaceutical Manufacturing

segregation challenges in pharmaceutical manufacturing

by: August Jorgensen and Brandon Johnson

The pharma industry is one of the largest growing markets due to advances in biotechnologies and market shifts from Covid-19. Unfortunately, it is also one of the most challenging industries to design equipment for because of the sanitary requirements, government regulations, material/ingredient properties, (and hard-to-pronounce words). The food industry can be a good starting point with some similarities in hygienic design and regulations. Still, the characteristic difficulties are unique, causing material segregation challenges in pharmaceutical manufacturing that cannot be overlooked.

Industrial plants can often be dirty with carbon black in every nook and cranny (at no fault to the plant – carbon is messy!) On the other hand, food plants can be enjoyable to walk into with a cleaner environment. Often, there is an aroma of sweets or familiar foods. While you can get away with unsanitary environments in industrial plants, or the sights and aromatic smells in food plants, this would be unacceptable in the pharma industry due to the potency of ingredients. If you walk into a pharma plant and see any indication of by-products on the ground or smell the aroma of an ingredient, you could be at risk of ingesting harmful levels of potent ingredients.

Pharmaceuticals Ingredients

There are many unique ingredients and common ingredients in the Pharmaceutical Industry (Pharma Manufacturing).

Active Pharmaceutical Ingredients (API)
An example of an API is acetylsalicylic acid, commonly found in aspirin. Or Atorvastatin Calcium, which can be found in Lipitor. These powders are critical to the end product i.e., medication, that a person needs.

A correctly designed pneumatic conveying system is crucial to pharmaceutical material handling. Whether it’s a hospital or dietary supplement company, if they’re making their products with the right ingredients and handling system then consumers will have no problem using them. Pneumatic conveying systems are crucial for transporting materials in an efficient manner which leads to better quality end products. 

If a pharmaceutical material handling system is not designed correctly, then the breakdown or contamination of the product can cause damaging repercussions.

Excipients
In many of the medications consumers take, fillers or binders are added to the API to help round out the medication. These fillers are called Excipients. Designing a well-functioning, efficient system to handle these excipients is just as critical, or even more critical, than handling the API. 

An example of an excipient is Sorbitol, which is found in antibiotics another is Starch found in pain-reliever over-the-counter medications. Corn, Sodium Starch Glycolate, Pregelatinized (cooked and dried), Cellulose, Hydroxypropyl (water and organic solubility), Microcrystalline, Calcium carbonate, Candelilla wax, Croscarmellose sodium, NF, lactose monohydrate, magnesium stearate, microcrystalline cellulose, Colloidal Anhydrous Silica, Gelatin, Titanium Dioxide, Lactose are also common powders. These excipients and others are found in many of the common medications used by American consumers.

The consequences of a material handling system that is not designed correctly can be devastating. From the loss of product and time to potential injury or even death – it’s important that these systems are precisely designed with safety in mind from day one!

Sorbitol
Sorbitol is a Carbohydrate (sugar alcohol) that behaves very similarly to sugar. HaF Equipment has installed many sugar handling systems. They are tricky. A few of the challenges are that Sorbitol is Hygroscopic, Combustible, and is Poor-flowing! Every surface, every hopper, every transfer point needs to be reviewed and designed with expert precision.

Cellulose
Cellulose is a common excipient. It is odorless, white, and fibrous. The fibrous structure of cellulose particles and the fact that cellulose is very fine and light causes many challenges when trying to transfer cellulose and ensure you don’t have a dust cloud in your plant!

Using pressurized air to move cellulose only packs the particles tighter and tends to plug. Also, when a plug forms, the backpressure in the system increases, and the chances of a dust cloud increase. Not good. The alternative is a vacuum conveying system. Instead of packing the particles together, a vacuum system pulls them apart and allows them to flow. And guess what, with a vacuum system, if there are any leaks in the piping system, air leaks INTO the system, instead of cellulose blowing OUT OF the system.

Titanium Dioxide 
A very difficult to handle excipient is Titanium Dioxide. TiO2 is used in pharmaceuticals as a pigment. It is also used in most sunscreens, like zinc oxide. Although this powder is a common ingredient in medication, it is difficult to handle. Titanium Dioxide is easy to compact because it has adhesive-like properties. The result is that when TiO2 is stored in a vessel, it can bridge (meaning it does free flow out of the vessel discharge point), rathole (meaning it sticks to the sidewalls of a vessel and the whole middle column empties while the other material stays in the vessel), and segregate (meaning various particle sizes separate inside a hopper). Great care is needed when handling TiO2. 

Common Segregation Challenges

With material handling in the pharmaceutical industry, every powder and liquid has unique properties; bulk density, particle shape, particle size, aeration capacity, etc., all impact how the powder behaves.

Segregation of particles in a system can cause many challenges from plugging in the hopper, buildup, and inconsistent batch integrity. There are several ways that material segregation can occur.

When the powder enters a storage hopper, segregation can occur as fine powders accumulate at the top. The powder particles are fluidized, and the lighter materials float to the top. The storage hopper is now full of a non-homogenous mixture of powder particles. 

Fine particles have lower permeability than coarse and retain air longer. This is common for mixtures below 100µm in size, making them more difficult to vent or filter out when high rates are used (as opposed to low). 

Dusting (Segregation)
Dusting is an example of particle entrapment. The dusting process occurs when larger particles separate from a mixture because of their slower settling speed and is seen more often with mixes below 50microns.

Sifting (Segregation)
Sifting Segregation is the sifting phenomena that causes segregation to occur in a lateral, or side-to-side motion. When this happens, fines (lighter materials) collect in the center under the point of impact, coarse particles roll off the pile and locate on the sides. Small particles move through a matrix of larger ones, and then segregation occurs. It happens when the difference in particle size is greater than 2:1, and the large average particle size is greater than 500µm and free-flowing.  

The Challenge of Degradation

A spray-dried powder or a delicate powder structure needs to be handled gently. Yet, it can be a challenge because the system has to be gentle while transferring the necessary API or excipient powder from one part of the plant to the other and do it fast enough to keep up production rates! So, how is this done?

The key is to handle the powder at low velocities. It is possible to use compressed air and move the powder very slowly. Dense Phase Pneumatic Conveying technology is one of the best and most efficient ways.

Summary 

With the growing demand for pharmaceutical manufacturing, precise material handling is more important than ever. HaF’s material handling equipment for pharmaceuticals is engineered to handle your pharmaceutical powders and materials with precision and accuracy. With our equipment, you’ll be able to optimize your production process and ensure that you’re meeting the high standards of the pharmaceutical industry.

CONTACT US today to discuss your pharmaceutical manufacturing equipment needs. 

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About HaF Equipment

HaF is a Minnesota-based company with employees spread out across the USA and capabilities world-wide. We’re ready to support your manufacturing industry needs no matter where you live or what type of industry – we’ve got our finger on the pulse Ready to Connect. 

For more information about how we can help you meet your goals, don’t hesitate to call us at (651) 653-5098, or complete the Contact Form on our website.

Material Handling in Pharmaceutical Manufacturing

pharmaceutical manufacturing

by Michael Thiel and Sarah Wagner 

The pharmaceutical industry is constantly changing and evolving, but how the pandemic affects it can be different from one year to another. There are no clear answers about what’s next; what is clear is that this is not an ideal situation, and companies need to keep up and be ready to change to remain relevant. 

Fortune Business Insights describes the change in the pharmaceutical landscape and the upcoming continual growth – “The global OTC Drugs market is projected to grow from $157.0 billion in 2021 to $233.6 billion in 2028 at a CAGR of 5.8% in forecast period, 2021-2028. 

With the ever-changing times, pharmaceutical material handling is critical for companies to adapt quickly and stay on top of the changes.

What are Pharmaceuticals?

The word “pharmaceutical” is an umbrella term for all medicines. It’s a very broad category that brings to mind many different images and thoughts from over-the-counter drugs to liquid medication.

Why Material Handling in Pharmaceuticals Matters

Pharmaceutical Manufacturing is an important part of the American economy and involves prescription drugs, hospital products, high-security drugs, small batch operations, decontamination rooms, syringes, narcotics,  vaccinations, and more.

Pharmaceutical material handling is a critical component to ensuring the safe and timely delivery of products – of both dry and liquid ingredients.

Having the correct Material Handling System for production is essential for reliability and business success.

The Material Handling Process in Pharmaceuticals

Pharmaceutical Manufacturing (Pharma Manufacturing) is the process of large-scale (anything greater than lab-scale) production of pharmaceutical drugs as part of the pharmaceutical industry. The process of drug manufacturing includes many steps and unit operations, such as: 

  • bulk bag unloading (e.g. super sacks)
  • small bag station (e.g. 50-Lb. Bags)
  • drum tipping stations (e.g. unloading drums)
  • pneumatic conveying systems (e.g. vacuum dilute phase)
  • filter receivers
  • surge hoppers
  • feeders
  • pumps
  • sifters
  • mills
  • granulators
  • dryers
  • chillers
  • packaging equipment.

Material Handling Systems in Pharma Manufacturing

When designing a Material Handling System for pharmaceutical manufacturing, it is essential to understand the ingredients, like the powders, involved. In Pharma Manufacturing, the handled materials are typically either an API or an Excipient.

What is an API? The Active Pharmaceutical Ingredient (API) is the potent active ingredient. Sometimes, the medication taken has a very small amount of API. The rest of the medication consists of necessary fillers. The “active pharmaceutical ingredient” (API) is any substance or blend of materials used in a finished pharmaceutical product (FPP)

What is an Excipient? Excipients are non-active ingredients and are often called bulking agents, fillers, or binders. The non-active ingredients can help with long term stability and potency in small amounts by acting as buffers to the formulation’s active components.

The Importance of Sanitary Design

The Food and Drug Administration (FDA) is responsible for ensuring that the quality and design of equipment used in pharmaceutical manufacturing protects consumers. The Material Handling System must meet their standards in order to be approved and sold in American markets, but it’s important not only to understand how they think-you need an expert who knows what will work.

There are various levels of sanitary design in the pharmaceutical manufacturing process, and sometimes documentation is required for certain equipment.

Design Philosophy of Sanitary Design

The equipment designer and supplier need to produce sound, sanitary products. Using a tool-free-quick-take-apart design philosophy helps to ensure this.

Though it is the customer’s specification that provide the level of sanitary design, typical materials used are stainless steel with finishes ranging from 304ss or 316-grade. The material finish should be to the level of a 2B or #4 finish. The welds would need to be ground flush and polished to a 20-32 ra.

The design philosophy of sanitary equipment considers the interior and exterior surfaces of the equipment. Minimizing any opportunity for dust or powder buildup on the exterior surface of the pharmaceutical manufacturing equipment must be considered. This is achieved by limiting horizontal surfaces so that dust and powder cannot collect. Interior surfaces are critical because that is where the ingredient is handled. Interior designs considerations include how easy it is to clean and a good line of sight.

When designing surge hoppers and vessels, the top of vessels should utilize domed or round tops to help prevent buildup. Control enclosures should be slope top. Support legs on vessels should be tucked under so that there are no ledges where support meets the main body and could harbor dust.

We have many more design considerations for every piece of equipment we design. If you want to know what those are, please CONTACT US, and let’s discuss in greater detail.

Dry Material Handling Equipment for Production Scale

Operator Exposure Limits (OEL’s) 

The importance of maintaining a safe work environment for operators cannot be understated. The Operator Exposure Limits (OEL) is what ensures that daily shifts go smoothly without major issues or injuries.

Generally, the pharmaceutical industry establishes internal occupational exposure limits at or below 10 µg/m3 as an eight-hour time-weighted average for highly potent drugs. The ratings for OEL’s are described in bands – Occupational Exposure Bands (OEB’s).

Learn more on the Pharmaceutical Guidelines Websites

Dust Hazard Analysis and Explosion Mitigation Equipment

The HaF team has a proven process for evaluating the hazards in your system design and providing you with best practices to ensure safety. Mentioning Kst or Pmax values is not enough. During our Dust Hazard Analysis (DHA) we walk through the process and system design with you to truly understand what’s happening at every stage of production and consult on the best approaches to design a safe and reliable system.

Summary 

When designing Pharmaceutical Manufacturing (the pharmaceutical market) equipment many factors need to be considered. At HaF, we have a passion for equipment design and sanitary applications. Our design philosophy is summed up as “Tool-Free -Quick-Take-Apart®”.

HaF cares about the operator that will use our equipment for years to come. CONTACT US today to discuss your pharmaceutical manufacturing equipment needs. 

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About HaF Equipment

HaF is a Minnesota-based company with employees spread out across the USA and capabilities world-wide. We’re ready to support your manufacturing industry needs no matter where you live or what type of industry – we’ve got our finger on the pulse Ready to Connect. 

For more information about how we can help you meet your goals, don’t hesitate to call us at (651) 653-5098, or complete the Contact Form on our website.

Keep It Clean: HaF’s Gravity Divert Valve

Gravity Divert Valve

HaF Equipment’s latest gravity divert valve is an ideal solution for those who need to upgrade their aging system with modern technology. This sanitary diverter valve will increase efficiency and help prevent expensive downtime due to inefficient and outdated systems. The gravity divert valve is built for sanitary applications and is fully accepted by the United States Department of Agriculture (USDA).

The focus for the gravity divert valve is on sanitary design and to provide an easy to clean divert valve positioned in the vertical orientation so that powder can flow and drop into either of two locations.

Using proven HaF design methods developed over 25 years, the gravity divert valve is part of our tool-free-quick-take-apart® designs developed for ease of cleaning. The main body of this sanitary diverter valve can be disassembled and wiped down because there are no hidden crevices. The sanitary ferrule connections allow for a clamp to easily be removed, gaining access to clean the connections and easily remove the gravity divert valve for cleaning.

Gravity Divert Valve for article

Custom Gravity Divert Valve

Although the most recent Gravity Divert Valve that HaF configured has 6-inch diameter chutes, our team is innovative. HaF can design custom down chutes for whatever application the customer needs. Its framework is solid and is structured with a heavy-duty actuator. This flow direction valve has a “Y” Divert Split Configuration with a 60-degree offset. Precisely designed, the gravity divert valve is built with a dual coil solenoid and has a Proximity Limit Switch with a Cable.

Gravity Divert Valves are available in different sizes to mix and match components depending on the customer’s needs and specifications.

About HaF

HaF is a Minnesota-based company with employees spread out across the USA and capabilities world-wide. We’re ready to support your manufacturing industry needs no matter where you live or what type of industry – we’ve got our finger on the pulse Ready to Connect. 

For more information about how we can help you meet your goals, don’t hesitate to call us at (651) 653-5098, or complete the Contact Form on our website.

A Simple Way to Deliver Pre-weighed Batches to a Mixer: Dense Phase Conveyor Case Study

Dense Phase Conveyor

A great way to speed up your batch production is to add a gain-in-weight dense phase conveyor. A recent customer used HaF Equipment to pre-weigh powdered limestone under a silo.  The dense phase conveying vessel also served as a weigh hopper.  When the mixer called for a new batch, the dense phase vessel transferred the pre-weighed batch of material.

The great part of dense phase conveying is that the batch can send long distances!  No matter where you locate your mixer, the Gain-In-Weight Dense Phase Conveyor, can deliver, and do so very quickly!

Dense Phase Conveyor Case Study

About HaF Equipment

HaF is a Minnesota-based company with employees spread out across the USA and capabilities world-wide. We’re ready to support your manufacturing industry needs no matter where you live or what type of industry – we’ve got our finger on the pulse Ready to Connect. 

For more information about how we can help you meet your goals, don’t hesitate to call us at (651) 653-5098, or complete the Contact Form on our website.